Fetal toxicity of local anesthetics
نویسنده
چکیده
This article reviews mechanisms by which local anesthetics may compromise the fetus during conduction analgesia in obstetrics. In addition to presenting pertinent information about perinatal pharmacology of local anesthetics, the author discusses comparative effects of 2-chloroprocaine and amide-linked compounds. Recommendations are made for prevention of maternal hypotension and local anesthetic-induced seizures.
منابع مشابه
The effect of nifedipine and baclofen on spinal anesthesia induced by local anesthetics
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The primary mode of action of local anesthetics is through sodium channel and axonal conduction blockade. Local anesthetics have also extensive effects on pre-synaptic calcium channels that must function to stimulate the release of neurotransmitters. Thus, interference with calcium channel conductance may enhance spinal anesthesia with local anesthetics. The present study was designed to invest...
متن کاملCardiovascular Toxicity of Local Anesthetics
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متن کاملمقاومت حقیقی به داروهای بیحس کننده موضعی: (گزارش مورد)
Background: We report a case with apparent resistance to local anesthetics. While regional anesthetics failure are often attributed to technical failure, the clinical presentation and medical history of this patient suggests a true resistance to local anesthetics. Case report: A 28 years old man was scheduled for elective orthopedic surgery for right sided tibial bone fracture, and decision of...
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تاریخ انتشار 2008